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Newsfeed display by CaRP Shingles is a disease caused by the varicella-zoster virus, the same virus that causes chickenpox. After an attack of chickenpox, the virus lies dormant in the nerve tissue. As we get older, it is possible for the virus to reappear in the form of shingles. Shingles is estimated to affect 2 in every 10 people in their lifetime. This year, more than 500,000 people will develop shingles. Fortunately, scientists are doing research to find a vaccine to prevent the disease.

Shingles is an outbreak of rash or blisters on the skin that is caused by the same virus that causes chickenpox — the varicella-zoster virus. The first sign of shingles is often burning or tingling pain, or sometimes numbness or itch, in one particular location on only one side of the body. After several days or a week, a rash of fluid-filled blisters, similar to chickenpox, appears in one area on one side of the body. Shingles pain can be mild or intense. Some people have mostly itching; some feel pain from the gentlest touch or breeze. The most common location for shingles is a band, called a dermatome, spanning one side of the trunk around the waistline.

Anyone who has had chickenpox is at risk for shingles. Scientists think that in the original battle with the varicella-zoster virus, some of the virus particles leave the skin blisters and move into the nervous system. When the varicella-zoster virus reactivates, the virus moves back down the long nerve fibers that extend from the sensory cell bodies to the skin. The viruses multiply, the tell-tale rash erupts, and the person now has shingles.

Although it is most common in people over age 50, if you have had chickenpox, you are at risk for developing shingles. Shingles is also more common in people with weakened immune systems from HIV infection, chemotherapy or radiation treatment, transplant operations, and stress.

Early signs of shingles include burning or shooting pain and tingling or itching generally located on one side of the body or face. The pain can be severe. Rash or blisters are present anywhere from 1 to 14 days.

If shingles appears on your face, it can lead to complications in your hearing and vision. For instance, if shingles affects your eye, the cornea can become infected and lead to temporary or permanent blindness. Another complication of the virus is postherpetic neuralgia (PHN); a condition where the pain from shingles persists for months, sometimes years, after the shingles rash has healed.

For most healthy people, the lesions heal, the pain subsides within 3 to 5 weeks, and the blisters leave no scars. However, shingles is a serious threat in immunosuppressed individuals — for example, those with HIV infection or who are receiving cancer treatments that can weaken their immune systems. People who receive organ transplants are also vulnerable to shingles because they are given drugs that suppress the immune system.

A person with a shingles rash can pass the virus to someone; usually a child, who has never had chickenpox, but the child will develop chickenpox, not shingles. A person with chickenpox cannot communicate shingles to someone else. Shingles comes from the virus hiding inside the person's body, not from an outside source.

The severity and duration of an attack of shingles can be significantly reduced by immediate treatment with antiviral drugs, which include acyclovir, valcyclovir, or famcyclovir. Antiviral drugs may also help stave off the painful after-effects of shingles known as postherpetic neuralgia. Other treatments for postherpetic neuralgia include steroids, antidepressants, anticonvulsants, and topical agents.

In 2006, the Food and Drug Administration approved a VZV vaccine (Zostavax) for use in people 60 and older who have had chickenpox. When the vaccine becomes more widely available, many older adults will for the first time have a means of preventing shingles. Researchers found that giving older adults the vaccine reduced the expected number of later cases of shingles by half. And in people who still got the disease despite immunization, the severity and complications of shingles were dramatically reduced. The shingles vaccine is only a preventive therapy and is not a treatment for those who already have shingles or postherpetic neuralgia.

There is no cure for shingles, but the severity and duration of an attack of shingles can be significantly reduced if you are treated immediately with antiviral drugs, which include acyclovir, valacyclovir, or famcyclovir. Antiviral drugs may also help stave off the painful after-effects of PHN. Other treatments for PHN include painkillers, steroids, antidepressants, and antiseizure medicine.

The National Institute of Allergy and Infectious Diseases, National Institute of Neurological Disorders and Stroke, and other institutes of the National Institutes of Health (NIH) conduct shingles research in NIH laboratories and support additional research through grants to major medical institutions across the country. Current research is aimed at finding new methods for treating shingles and its complications.

In May 2006, the Food and Drug Administration approved use of a vaccine to prevent shingles. The vaccine, called Zostavax, is recommended for people 60 years of age and older who have had chickenpox but whom have not had shingles. Researchers estimate the vaccine could prevent 250,000 cases of shingles that occur in the United States each year and significantly reduce the severity of the disease in another 250,000 cases annually.